HAMYCIN

HAMYCIN

Brand Name : Primamycin

Hamycin is a polyene antibiotic complex produced by Streptomyces primprina. At one time, hamycin was believed to be identical to trichomycin and candicidin. Subsequent HPLC studies have shown the three polyene antibiotics to be different compounds. Structural study showed that hamycin was a mixture of components A, B, C and D.

Hamycin occurs as a yellow amorphous powder with no definite melting point. It decomposes at 1609. It is an amphoteric compound which is almost insoluble in water, benzene, chloroform, lower aliphatic alcohols and ether; soluble in basic solvents such as pyridine, collidine, and in aqueous lower alcohols. In concentrated sulphuric acid it forms stable blue colour.

Hamycin has been reported to have antifungal and antitrichomonal properties. It has been administered topically and by mouth in a variety of fungal infections.




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