HYDROCHLOROTHIAZIDE

HYDROCHLOROTHIAZIDE



Brand Names : Aquarius; Bremil; Chlorosulthiadil; Chlorzide; Cidrex; Dichlorosal; Dichlotride; Diclotride; Direma; Disalunil; Esidrex: Esidrix: Fluvin; Hidroronol; Hydril; Hydro-Aquil; HydroDiurill; Hydrosaluric: Hydrothide; Hypothiazide; Ivaugon; JenDiril; Maschitt; Nefrix; Neo-Codema; Neoflumen; Oretic; Panurin; Ro-Hydrazide; Thiaretic; Thiuretic; Urodiazin; Vetidrex.



Reduction of the 3,4-position of the thiadiazine ring increases activity of the benzothiadiazines, lowers the toxicity and increases the activity by about 10 times.



Hydrochlorothiazide is a reduced derivative of benzothiadiazine. It is a white, odourless, crystalline powder, m.p. 273-275°, slightly soluble in water, alcohol and methanol;soluble in acetone; freely soluble in dimethylformamide , n-butylamine and solution of alkali hydroxides; insoluble in ether, chloroform and dilute mineral acids; stored in well closed containers.



Uses : Hydrochlorothiazide is a diuretic with actions, uses and adverse effects similar to those of chlorothiazide.




Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more