ISONIAZ|D

ISONIAZ|D

Brand Names: INH; Rimitsid; RP 5015; FSR-3 Cedin (Aerosol). Isocid; Neoxin; Hidrasonil; Ertuban; Antimicina: Hyzyd; Isonex; Unicozyde; Zonazide; Hycozid; Niconyl; Isonicazide; Isonicid: Isonicotan: Tubizid: Tibizide; Isolbicina: Isozide: Isonikex; Isonindon: Isotebezid; Nicetal; Nikozid; Nitadon: Nyscozid; Pelazid; Raunanon: Retozide: RU-EF-Tb: Tebecid: Tisiodrazide: Tizide: Isozyd; Sauterazid; Nevin; Cotinazin; Dinacrin; Ditubin; Mybasan; Neoteben; Niadrin; Nicozide; Nydrazid; Nidaton; Nicizina; Nicotibina; Pycazide; Pyricidin; Isolyn; Pyrizidin; Rimifon; Robisellin: Isonizide; Neumandin: Isocotin; Tubicon: Tyvid: Tisin; Tibinide; Tubiysin; Tubomel; Tubeco; Atcotibine; Vazadrine; Vederon; Isonidrin; Zinadon. Niplen; TB-Vis; Takazin; Iridrina; Hydrazid.


Isoniazid, the hydrazide of isonicotinic acid, is synthesized from Y-picoline, which by permanganate oxidation is converted in the normal manner into isonicotinic acid. The acid is esterified by means of " ethanol and concentrated sulphuric acid. Direct N2 condensation of the ester with hydrazine affords the required hydrazide.


lsoniazid occurs as colourless, odourless crystals, or white crystalline powder, m.p. 171.4°. soluble in water (1 : 8) and alcohol (1 : 50); slightly soluble in chloroform and ether. The drug is stored in well-closed containers and protected from light
 .


Uses
Isonlazid is antibacterial (tuberculostatic), i.e., it has N bacteriostatic effect on the tubercle bacilli therein. It is used to treat pulmonary and extrapulmonary tuberculosis. Pyridoxine N is often given in conjugation with isoniazid to avert its neurotoxicity .






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