LIGNOCAINE

LIGNOCAINE

Brand Names : Lidocaine; Xylocaine; Xylotox; Leostesin; Rucaina; Isicaine; Dunçaine; Xylestesin; . Anestacon; Gravocain; Lidothesin; Xylocitin.

Lignocaine, m.p. 68-69, is a white, crystalline odourless substance which is insoluble in water; soluble in alcohol, ether, benzene, chloroform and oils.

Lignocaine hydrochloride (Brand Names : Xylocard; Xyloneural; Lignostab; Nurocain) m.p. 127-129, is a white crystalline odourless powder which is soluble in water, alcohol and chloroform. The hydrochloride or amine is the most stable local anaesthetic. The ester-type local anaesthetics are generally prone to hydrolysis in aqueous solution,

Use
Lignocaine is a local anaesthetic and antiarrhythmic .

Adverse Effect
Lignocaine has systemic adverse effects mainly involves the central nervous system and the cardiovascular system. Excitation of the CNS may be manifested by restlessness, excitement, nervousness, diizziness, tinnitus, blurred Vision, nausea and yonaiting, muscle-twitching and tremors and convulsions. Numbness of the tongue and perioral region may appear. Excitation may be transient and followed by depression with drowsiness, respiratory failure, and coma.



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