MEBENDAZOLE


MEBENDAZOLE



Brand Names : Ovitelmin; Pantelmin; Telmin; Vermirax; VermOX; R 17635.



Mebendazole, a benzimidazole carbomate derivative, occurs as a white to slightly yellow powder; m.p. 288-289; practically insoluble inwater, alcohol, chloroform, ether and dilute mineral acids; freely soluble in formic acid.


Uses:



It is an anthelmintic with activity against most nematode and some cestode. It is poorly absorbed from the gastro-intestinal tract and is used principally to treat infections due to roundworms threadworms, hookworms and whipworm. During treatment with mebendazole, migration of worms with expulsion through the mouth and nose occurred in some patients. It is also used in the treatment of  capilliariasis .



Side effect


Side effects have generally been restricted to gastro-intestinal disturbances such as transient abdominal pain and diarrhoea




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