MEPYRAMINE

MEPYRAMINE

Brand Names : Pyrilamine; Pyranisamine; RP2786; Neo-Antergan; Anthisan; Antallergan; Harvamine; Isamin; Pyra; Kriptin, Thylogen; Wait's Green; Mountain Antihistamine; Paraminyl; Maranhist; Histapyran; Histasan; Histalon; Histacap; Coradon; Copsamine, Antamine; Afko-Hist: Mepyren; Neo-Bridal; Pyramal:




Mepyramine is a substituted  2-aminopyridine which is prepared by heating pyridine in a suitable solvent with sodamide. The nucleophilic amino group enters at the position adjacent to the nitrogen atom.




Mepyramine is an oily liquid, b.p.2019. It is used as maleate salt.




Mepyramine maleate (Brand Names: Dorantamin; Enrumay Histan; Histatex; Histosol; Paraminyl maleate; Stamine), m.p. 100-101°, is a white or creamy-white, crystalline, odourles powder. 


It is soluble in water, alcohol and chloroform; slightly soluble in ether. A 2% solution in water has a pH of 4.9 to 5.2 It is stored in airtight containers and protected from light.


Uses:

 Mepyramine is an antihistamic agent used in the treatment of allergic conditions. It is employed locally for insect bites and stings and for allergic and pruritic skin conditions.


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