MERCAPTOPURINE

MERCAPTOPURINE

Brand Nannes: 6-MP; Leukerin; Merca leukin: Purinethol; NSC755; Purinethiol; WR -2785.


Mercaptopurine, m.p. 313-3149 (decomp), is a yellow, odourless, crystalline powder. It is practically insoluble in water, acetone and ether; slightly soluble in alcohol; soluble in hot alcohol and in solutions of alkali hydroxides; slightly soluble in M sulphuric acid. It is stored in air-tight containers and protected from light.


Mercaptopurine acts as an antimetabolite for adenine in the synthesis of nucleotides by living cells. It is thought to act by entering leukaemic blood cells and interfering with their function.


 It is metabolized in the body to 6-thiouric acid. After the intracellular conversion of mercaptopurine to active nucleotides, it interferes with nucleic acid synthesis.



Uses: Mercaptopurine is an antineoplastic agent which acts as an antimetabolite. It also has immunosuppressant properties. It is used, usually with other agents, in the treatment of leukaemia and various auto-immune disorders.


Side Effect


The side-effects of mercaptopurine include bone-marrow depression, hypoplasia and hepatotoxicity.


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