METHACYCLINE HYDROCHLORIDE

METHACYCLINE HYDROCHLORIDE



Brand Names : GS-2876 (methacycline); Methylenecycline hydrochloride; Metacycline hydrochloride; Metacyclini Chloridum; Adriamiana; Ciclobiotic; Germiciclin; Globociclina; Megamycine; Metadomus; Metilenbiotic; Londomycin; Optimycin; Rondomycin; Physiomycine; Rindex




Methacycline is synthesized by chemical modification of oxytetracycline. Its antibiotic spetrum is similar to the other tetracyclines but its potency is greater than the other such compounds. The greater stability of methacycline is due to the modification at carbon atom 6. The substitution of the 6-hydroxy group markedly increases the stability of ring C to both acids and alkalies, by preventing the formation of anhydrotetracyclines by acids and ofisotetracyclines by bases.



Methacycline hydrochloride, m.p. 205 (decomp.), is a yellow to dark yellow crystalline powder. 


It is slightly soluble in water (1 in 100) and in alcohol (1 in 300); practically insoluble in chloroform and ether; soluble in dilute solutions of Sodium hydroxide. It should be stored in tight and light-resistant containers in a cool place




Uses

 Methacycline hydrochloride has the same antimicrobial activity


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