METHADONE HYDROCHLORIDE

METHADONE HYDROCHLORIDE
Brand Names : Dolophine; Amidine; Phenadone; Adanon HCl: Algidone; Algolysin; AN-148; Butalgin; Amidon HCl; Depridol: Diaminon HCl: Fenadone; Heptadon HCl: Hoechst 10820; Mecodin; Mephenon; Miadone; Moheptan; Physeptone HCl: Tussa


Methadone is prepared by condensing diphenylmethyl cyanide with 2-chloro-1-dimethyl aminopropane in the presence of sodamide. The intermediate cyclic quaternary ammonium salt undergoes cleavage to yield a mixture of amines. The amines are hydrolyzed to a mixture of ketones which are separated. One of these ketone is methadone.



Methadone hydrochloride, m.p. 235°, is a colourless, odourless crystalline powder with a bitter taste. It is soluble in water; freely soluble in alcohol and chloroform; practically insoluble in ether and glycerol. A 1% solution in water has a pH of 4.5 to 6.5.

Uses: Methadone is a potent analgesic with actions, uses and side effects similar to those of morphine. It is used to alleviate many types of pains and has a depressant action on cough Centre.


The toxicity of methadone is 3 to 10 times greater than that of morphine. It has analgesic effect twice that of morphine and relatively greater respiratory depressant effect than morphine. Pulmonary oedema after over dose is common.

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