METHYLDOPA

METHYLDOPA





Methyldopa is a colourless or a white to yellowish - white, odourless, fine powder which may contain friable lumps; m.p. - 300 (decomp). 



It is slightly soluble in water and alcohol; practically insoluble in chloroform and ether; dissolves in dilute mineral acids.


 It is kept in well-closed containers and protected from light.



Methyldopate Hydrochloride (Brand Names : Aldomet Ester Hydrochloride) is a zwitter ion and is not soluble enough for parenteral use. It is soluble in water to the extent of 10-300 mg/ ml at pH 2-7. It may be stabilized with sodium bisulphite or disodium EDTA. 


It is a white, odourless, crystalline powder which is slightly soluble in chloroform; practically insoluble in ether.


Uses : Methyldopa and its derivatives are antihypertensive .


Side Effect


The common side effects include depression, psychic effects, nightmares, nausea, dryness of the mouth, headache, dizziness, oedema and disorders of sexual function.



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