METRONIDAZOLE

METRONIDAZOLE




Brand Names :  Bayer 5630; RP 8823; Arilin; Clont; Cont; Danizol; Deflamon;
Flagyl; Fossyol; Gineflour; Klion; Orvagil; oN NS-CH3 Sanatrichom; Trichazol; Trichocide; Tricho s Cordes; Tricho-Gynaedron; Tricocet; N Trivazol; Vagilen; Vagimid.



Metronidazole is an imidazole or cyclic amidines which can be synthesized by condensation of compounds containing adjacent carbonyl group (i.e.-CO-CO) with ammonia and formaldehyde (Radziszewski's reaction).



 Tartaric acid dinitrate and acetaldehyde yields, after thermal decarboxylation, 2-methylimidazole. Nitration, followed by alkylation in the 1-position with ethylene chlorohydrin yields metronidazole.

Metronidazole is a pale yellow or cream-coloured crystalline compound, m.p. 150-160; has limited solubility in water and other organic solvents. It is stable in air but darkens on exposure to light. Therefore, it is protected from light

Uses  



Metronidazole is an antiprotozoal substance and used in bacterial infections, anaerobic of malignant neoplasms. Darkened urine may occur when the drug is given in higher doses. The yellow pigment may be a metabolite of metronidazole. The adverse effects of the drug are gastro-intestinal disturbances, nausea, unpleasant taste, headache, anorexia and vomiting.




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