NEOMYCIN SULPHATE

NEOMYCIN SULPHATE



Brand Names : Fradiomycin sulphate; Neomycini sulfas; Mycifradin; Neobiotic.

Neomycin sulphate is a mixture of the sulphates of the antimicrobial substances produced by the growth of certain selected strains of Streptomyces fradiae. 


It occurs as a white or yellowish-white, odourless, hygroscopic, photosensitive, and crystalline powder. It is very soluble in water; slightly soluble in alcohol and insoluble in acetone, chloroform, and ether) It is stored at a temperature not exceeding 30° in airtight containers and protected from light.


Uses

Neomycin sulphate is used to treat infections of the skin and eye due to susceptible staphylococci and other organisms, as well as in ear-drops. A cream containing neomycin sulphate and chlorhexidine hydrochloride has been used for application to the nostrils in the treatment of staphylococcal nasal carriers. It is most useful antibiotic in the treatment of gastrointestinal infections dermatologic infections and acute bacterial peritonitis. It is also employed in abdominal surgery to reduce complication due to infections from bacterial flora of the bowel. It is very slightly absorbed from the digestive tract, so its oral use does not produce any systemic effect.

Adverse Effect

Adverse effects of neonsiycin are the same as in case of gentamicin sulphate. It may cause irreversible deafness when given by injection or by mouth. In large doses it may cause nausea, vomiting, and diarrhoea. Prolonged oral therapy may cause a malabsorption syndrome with steatorrhoea and diarrhoea Neomycin has a neuromuscular blocking action.






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