NEOSTIGMINE

NEOSTIGMINE



Brand Names: Synstigmin; Proserine; Intrastigmina; Juvastigmin; Neostigmin: Normastigmin; Prostigmine



Neostigmine bromide, m.p. 167 (decomp), occurs as a hygroscopica bitter, odourless, colourless crystals or white crystalline powder. 


It is soluble in water, alcohol, and chloroform; practically insoluble in ether; stored in airtight containers and protected from light.

Neostigmine methylsulphate also occurs as odourless, colourless crystals or a white crystalline powder; soluble in water and alcohol.


Uses: 


Neostigmine is cholinergic and used to stimulate peristalsis in post-operative distension, in the treatment of henia gravis, to curtail the muscular relaxation produced by nondepolarising muscle relaxants and in the treatment of paralytic illeus and postoperative urinary retention.

Side Effect


The side effects of neostigmine are chiefly due to excessive cholinergic stimulation and include increased salivation, nausea. vomiting, abdominal cramps and diarrhoea. Allergic reactions




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