NORADRENALINE

NORADRENALINE.



Brand Nanes : Norepinephrine; Levarterenol




Noradrenaline, the catecholannine, is also a product of the adrenal medulla.It is liberated at sympathetic nerve endings when they are in action.



 It is the lower homologue of adrenaline and is a primary amine rather than a secondary amine .
The i-form the demethylated precursor of epinephrine, occurs in animals and man. A synthesis identical to that of adrenaline is used. In an another preparative method protocatechuic aldehyde is the starting material.


The racemic mixture can be resolved by formation of (+)- acid tartrates. The dil-form, m.p. 191°, is sparingly soluble in water; very slightly soluble in alcohol, readily soluble in dilute acids and alkalies. L-From, also known as levarterenol, Adrenor and Levophed, occurs as microcrystalline powder, m.p. 216-218°. l-Form hydrochloride (synonym, Arterenol), m.p. 145147, is freely soluble in water. Solutions are slowly oxidized under the influence of light and oxygen.


L-Form Bitartrate (Brand Names : Levarterenol bitartrate; Aktamin; Binodrenal) 

It is a white, crystalline powder, m.p. 1021049; when anhydrous, m.p. 158-159. It darkens on exposure to air and light. It is soluble in water (1 in 2.5), and alcohol (1 in 300); practically insoluble in chloroform and ether; stored in airtight containers and protected from light.


Uses : Noradrenaline is a sympathoninetic agent used to maintain blood pressure in acute hypotensive states resulting from trauma, central vasomotor depression and haemorrhage.

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