NYSTAIN





Brand Names: Fungicidin, Biofanal; Diastatin; Candex; CandioHermal; Mycostatin; Moronal; Multilind; Nystan; Nystavescent; O-V Statin; Nistatina; Nystatinum.


Nystatin is an antifungal substance produced by the growth of certain strains of Streptomyces noursei. It contains mainly tetraenes, the principal component being nystatin A. 

It is a valuable substance used to treat both internal and local infections of Candida albicans. The sugar moiety attached to the aglycone is mycosamine, 3,6-dideoxy-3-amino-D-mannose.



Nystatin is a light yellow to light brown hygroscopic powder with a characteristic cereal-like odour; gradually decomposes above 1609 without melting by 250°.

 It exhibits strong reducing properties. It is very soluble in water; slightly soluble in methanol; insoluble in alcohol, chloroform, and ether, freely soluble in dimethyl formamide.

 It is unstable to moisture, heat, light and air, and its solutions are inactivated rapidly by acids and bases. Solutions and aqueous suspensions begin to lose activity soon II after preparation. Aqueous suspensions are stable for 10 minutes on heating to 100° at pH 7.0; also stable in modertely alkaline  media. It is stored at a temperature between 2 to 8° in airtight containers and protected from light.



Uses : Nystatin is used for the prophylaxis and treatment of a candidiasis of the skin and mucous membranes, especially that e1 caused by Candida albicans. It is also given as eye-drops or as a bladder wash .


Side Effect
Nausea, vomiting, and diarrhoea have occasionally been reported after the oral administration of nystatin. Irritation may occur rarely after the topical use of nystatin, and allergic contact dermititis has been reported.





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