PAMAQUINE

PAMAQUINE





Brand Names : Plasmochin; Aminoquin; Praequine; Beprochine; Gamefar; Quipenyl;Plasmoquine.

It was the first successful 8-aminoquinoline derivative which was introduced by Germans in 1826. It may be synthesized by condensing 6-methoxy-8-aminoquinoline (I) with 1diethylamino-4-bromopentane (II).




Pamaquine occurs as dark yellow oil.



Pamaquine phosphate (Brand Names : Primachin phosphate; Primaquini diphosphas; Primaquinium phosphate; SN-13, 272) is an orange-red, odourless, crystalline powder. It is soluble in water (1 in 16); practically insoluble in chloroform and ether. It is protected from light.


Uses : Primaquine is an antimalarial effective against exoerythrocytic forms of the plasmodia parasite, and is a gametocyticide. Primaquine is generally well tolerated at normal therapeutic doses.

Adverse Effect

Adverse effects include abdominal cramps, gastric distress. nausea and vomiting, headache, visual disturbance, and pruritus.


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