PARACETAMOL

PARACETAMOL



Brand Names: Acetaminophen; p-Hydroxyacetanilide; Acamol; Alpiny; Anhiba; Ben-4-ron; Bickie-imol; Dial-a-gesic; Doliprane; Temlo, Valadol; Cetadol; Acetalgin; Enelfa; Exdol, Finimal; Datril; Dirox; Nobedon; APAP; Tabalgin; Tempra, Calpol, Dymadon; Momentum: Naprinol; Panets: Homoolan; Febrilix; Abensanil; Anaflon: Amadil; Eneril; Tralgon; Hedex: Pacemo: Panex , Parmol; Tylenol; Panadol; Lyteca; Apamide; Tapar; Gelocatil; Korum; Paraspen.




This is prepared by reduction of p-nitrophenol in glacial acetic acid, acetylation of p-aminophenol with acetic anhydride or ketone, or from p-hydroxyacetophenone hydrazone.



Paracetomol, m.p. 169-171°, is a white odourless crystalline powder with a slightly bitter taste. 

It is soluble in water (1:70: considerably more soluble in hot water (1:20) and in alcohol (l: 10); very slightly soluble in chloroform and ether; insoluble in petroleum ether, and benzene. It is kept in airtight containers and protected from light.



Uses : Paracetamol has analgesic and antipyretic properties.


Side Effect
Side-effects of paracetamol therapy are haematological reactions and skin rashes.





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