PAS

PAS




Brand Names : Deapasil; Apas; Apacil; Hellipidyl; PAC-C; Pamacyl; Parasal; Pascorbic; Pasolac; Parasalicil, Parasalindon; Pasnodia; Propasa; Rezipas; Sanipirol -4; Pamisyl; Para-Pas.


It forms minute crystals from alcohol, odourless or slight acetous odour, which darken on exposure to light and air. m.p.150-151; one gram dissolves in about 500 ml water, in 21 ml alcolol; slightly soluble in alcohol; insoluble in benzene: soluble in dilute nitric acid and dilute sodium hydroxide. Attemperatures above 40°, aqueous solutions of PAS and its hydrochloride are readily decarboxylated to give brown solutions consisting mainly of m-aminophenol. The drug is stored at a temperature not exceeding 30° in airtight containers and protected from light .

Uses



PAS is a tuberculostatic agent and retards the growth of actively multiplying tubercular bacilli. PAS aids streptomycin or dihydrostreptomycin in the treatment of tuberculosis. It is
completely and readily absorbed after oral administration. It is distributed freely and equally to most tissues and fluids with the exception of the cerebrospinal fluid. It is excreted in the urine,
both unchanged and as metabolites and has a biologic half-life of about 2 hours.
The main use of PAS is that it delays development of resistance to tuberculotic drugs
The toxic effects of PAS is that it tends to cause gartrointestinal disturbances with occasional skin rashes, allergic reactions and hypersensitivity .







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