PETHIDINE AND ANALOGUES

PETHIDINE AND ANALOGUES

Brand Names : Isonipecaine; Meperidine.

Pethidne Fentanyi Pethidine is a derivative of piperidine and is synthesized by treating benzyl cyanide with di-(2-chloroethyl) methylamine followed by hydrolysis and esterification of the resultant product.

Pethidine is a strong tertiary base and an ester. It is used as a hydrochloride salt which is an analgesic with a morphinelike action.



Pethidine Hydrochloride (Brand Names: Algil; Alodan; Dolantin: Dolestine; Dolenal; Demerol hydrochloride; Dolosal; Endolat: Dispadol; Dolvanol; Dolicontral; Dolomeurin (e); Centralgin; Dolopethin; Mefedina; Pantalgine; Sauteralgyll; Spasmedal; Spasmodolin; Mephedine; Lydol; Lidol; Synlaudine). m.p. 1861899. It is a fine white odourless crystalline powder which is very soluble in water; freely soluble in alcohol, acetone, ethyl acetate and chloroform; practically insoluble in ether and benzene. It is kept in airtight containers and protected from light.

Uses:


It is a narcotic analgesic agent used for the symptomatic relief of pain, to alleviate the anxiety associated with pain; as general anaesthetic in high doses.
It is also used as pre-operative medication and as an adjunct to anaesthesia. It has little effect on cough and diarrhoea.

Side Effect.


The common side effects of morphine are nausea, vomiting constipation, drowsiness, and confusion. Dry mouth, sweating. facial flushing, vertigo, bradycardia, palpitation, orthostatic hypotension, hypothermia, restlessness, changes in mood and miosis also occur. Abuse leads to habituation or addiction.



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