PHALYSULFATHAZOLE

PHALYSULFATHAZOLE





Brand Names : Entexidin; Entexidina; AFI-Ftalyl; Enteramida; ' Entero-Sulfina; Ftalazol; Intestiazol; Sulfacetil; Sulftalyl; Taleudron; Talidine; Thalistatyl; Ultratiazol; Thalazole.



It is prepared by condensing sulfathiazole with phthalic anhydride

The compound is an odourless, white, crystalline powder with slightly bitter taste. It slowly darkens on exposure to light; efferverces at 244-250 and then melts at 272°-277 (dec).



 It is insoluble inwater and chloroformandslightly soluble in alcohol and ether; readily soluble in strong acids and alkalies and ammonia water and liberates carbon dioxide from a solution of sodium bicarbonate

Uses
    Phthalylsulfathiazole is an intestinal antibacterial agent and is used in the treatment of bacillary dysentery and to reduce the bacterial count in the large bowel in patients undergoing surgery. Like succinylsulfathiazole, this compound is poorly absorbed from the intestinal tract. Because of its low absorption and low toxicity, compared with sulfaguanidine, it is useful in intestinal infections




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