PHENACEMIDE

PHENACEMIDE




Brand Names : Phenylacetylurea; Epiclase; Pharcetur; Phenurone; Phetyl ureum.



Phenacemide is prepared by the action of aqueous ammonia on phenacetylurethan or by the action of phenacetylchloride on urea.


 It occurs as an odourless, white, fine crystalline powder, m.p. 212-216°. It is very slightly soluble in water, alcohol, chloroform and ether; slightly soluble in acetone and methyl alcohol. It is stored in airtight containers. 

Uses: Phenacemide is an acetylurea antiepileptic agent used in the treatment of epilepsy, especially in the psychomotor type of seizure. Due to its potential toxicity it should be employed only in patients whose seizures are impossible to control with other recognized anti-epileptics.



Adverse Effect



Severe adverse effects reported with phenacemide include personality changes, blood disorders including aplastic anaemia, and liver and kidney damage.


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