PHENELZINE

PHENELZINE




Phenelzine is an aralkyl derivative of the inorganic base, hydrazine, NH, -NH. It is synthesized from 2-phenylethanol,  which on treatment with phosphorus pentachloride yields phenethyl chloride which on condensation with hydrazine produces phenethylhydrazine.



Phenelzine sulphate (Brand Names: W-1544a; Nardil; Estinerval; Kalgan; Nardelzine; Phenodyn; Stinerval) 

It is a white or yellowish white powder with a peculiar odour; soluble in water (l in 7); practically insoluble in alcohol, chloroform, and ether; stored in a cool place in airtight containers and protected from light.



Uses: Phenelzine is used in the treatment ofneurotic ora typical depression.

Adverse Effect

Adverse effects of phenelzine include orthostatic hypotension, dizziness, drowsiness, headache, weakness and fatigue, dryness of mouth, constipation, nausea and vomiting.



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