PILOCARPINE

PILOCARPINE




Brand Names : Chibro pilocarpine; Ocusert Pilo.




Pilocarpine, m.p. 34°, is an alkaloid obtained from the dried leaflets of Pilocarpus jaborandi , or Pilocarpus microphyllus (Family Rut-aceae). It occurs as colourless, translucent, odourless, faintly bitter crystals or as a viscous, hygroscopic, oily liquid. It is soluble in water, alcohol and chloroform; sparingly soluble in ether; stored at a temperature not exceeding 8° in airtight containers; protected from light.



Pilocarpine hydrochloride, m.p. 204-205, (Brand Names: Almocarpin, Pilomiotin; Isopto carpine; Pilovisc)isanodourless, hygroscopic, colourless crystalline powder; soluble in water, alcohol and chloroform; practically insoluble in ether; stored in airtight containers and protected from light.





Uses : Pilocarpine is a parasympathomimetic agent with primarily the muscarinic effects of acetylcholine. It is most commonly used to reduce intraocular pressure in the treatment of openangle glaucoma. It is antiglaucoma and cholinergic agent.

Side Effect


Adverse effects of pilocarpine are the same as for neostigmine. It may produce ciliary spasm, ocular pain and irritation, blurred vision, and headache.



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