PRIMIDONE

PRIMIDONE




Brand Names : Lepsiral; Liskantin; Mylepsin; Mylepsinum Mysoline; Primaclone; Primoline; Resimatil; Sertan.




Primidone is a diketone derived from hexahydropyrimidine. The chemical nature of primidone is similar to that of a cyclic diamide, and it has none of the acidic character of barbituric acid and the barbiturates, which have -CO- and not -CH,-between the two nitrogen atoms. It is prepared from phenobarbitone by electrolytic reduction




Primidone, m.p. 281-282°, is white, odourless, tasteless, crystalline powder. It is soluble in water (1 in 2000) and alcohol (1 in 200); very slightly soluble or practically insoluble in most organic solvents.


Uses : Primidone is an anticonvulsant agent used chiefly to control epileptiform seizures, i.e. grand mal and partial (focal) Seizures.



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