PROGUANIL HYDROCHLORIDE

PROGUANIL HYDROCHLORIDE





Brand Names : Bigumalum; Chloriguane hydrochloride; Chloroguanide hydrochloride; Proguanide hydrochloride; Proguanili hydrochloridum; RP-3359: SN-12.837; Guantol; Paludrine





Proguanil hydrochloride is a white, odourless, bitter, crystalline powder that is slightly soluble in water, more soluble in hot water, soluble in alcohol (1 in 40); practically insoluble in chloroform and ether. It is stable in air but slowly darkens on exposure to light. Therefore, it is protected from light.




Uses: Proguanil is used as an antimalarial drug and to reduce transmission of infection. It is active against pre-erythrocytic forms and is a slow blood schizontocide.




Side Effect
Proguanil hydrochloride is well tolerated after usualdoses; after large doses vomiting, epigastric discomfort, haematuria, and renal irritation may occur.


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