PROMETHAZINE

PROMETHAZINE

Band Names: Proazamine: RP 3277: RP H3 S389; Hiberna; Vallergine; Dimapp.

Promethazine is a phenothiazine derivative which is prepared by condensing phenothiazine with CICH2 CH(CH3)N (C2H5)2 in the presence of sodamide.

Promethazine is prepared from 10-phenothiazinepropyl chloride and dimethylamine in the presence of copper: and from Grignard complexes of dimethylaminopropyl halide and phenothiazine.

Promethazine, m.p. 60°, is a crystalline compound and used in the form of hydrochloride salt. -

Promethazine hydrochloride (Brand Names: Atosil; Fargan; Fenazil; Provigan; Prorex; Diphergan; Ganphen; Fellozine; Remsed; Dorme; Fenegan; Lergigan; Phencen; Phenergan; Promantine; Promine; Protazine; Prothazine; Thiergan), m.p. 230-232° (decomp); 


It is a white, odourless powder which is very soluble in water; soluble in alcohol and chloroform; practically insoluble in ether, acetone and ethyl acetate. It turns blue on prolonged exposure to air and moisture. It is keptinairtight containers and protected from light.

Uses : Promethazine is an antihistaminic agent having some antimuscarinic, antiemetic, antiserotoninergic and local anaesthetic properties. It is given for allergic conditions and to treat burns.


Side Effect

The side effects include sedation, drowsiness, lassitude, dizziness, and inco-ordination. Cardiovascular side-effects are more commonly observed after injection. Bradycardia, tachycardia, increase in blood pressure, hypotension, jaundice and thrombocytopenic purpura have been reported.



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