PROPRANOLOL HYDROCHLORIDE

PROPRANOLOL HYDROCHLORIDE




Brand Names: Avlocardyll; AY-64.043; ICI-4552O; NSC-91523: . Berkolol: Beta-Neg; Caridorol; Deralin; Dociton; Frekven; Inderal; gj Inderex; Indobloc; Kemi; Oposim; Pylapron; Rapynogen; Tesnol.





Propanolol is an ether of 1-naphthol . Its hydrochloride occurs as a white or creamy-white, odourless, crystalline powder; soluble in water (1 in 20) and alcohol; slightly soluble in chloroform; practically insoluble in ether, benzene and ethyl acetate. In aqueous solutions propranolol decomposes with oxidation of the isopropylamine side-chain, accompanied by a reduction in pH and discolouration of the solution. Solutions are most stable at pH 3 and decompose rapidly when alkaline. The compound is stored in well-closed containers and protected from light.



Uses:

Propranololis a cardiac depressant (anti-arrhythmic) and adrenergic blocker. It reduces the rates and f of the heart and decreases the rate of conduction of impulses. It is us the treatment of hypertension, cardiac arrhythmias, to improve the tolerance to exercise in patients with angina pectoris, bronchial asthma, allergic rhinitis during pollen season, etc.


Side Effect
The most common side effects of propranolol are nausea, vomiting and other gastro-intestinal disturbances, fatigue and dizziness.



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