PROPYLIODONE

PROPYLIODONE

Propyliodone, m.p. 186-187°. is the propyl ester of 3,5-di-iodo-4-pyridone-N-acetic acid. It occurs as a white; almost odourless, crystalline powder which is practically insoluble in water; slightly soluble in alcohol and in chloroform, very slightly soluble in ether. It is kept in airtight containers and protected from light.


Hydrolysis by means of boiling sodium hydroxide solution and subsequent acidification yields the butyric acid. It is used as a sterile aqueous or oil suspension for instillation into trachea prior to bronchography.




Uses : Propyliodone is used as a diagnostic aid (radiopaque medium) for the examination of the bronchial tract.



Side Effect

Propyliodone may give rise to transient pyrexia, sometimes associated with malaise and aching of the joints. In few cases dyspnoea, transient lobar collapse and allergic reactions may also occur.


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