PYRIDOSTIGMINE BROMIDE

PYRIDOSTIGMINE BROMIDE




Brand Names : RO 1-5.130; Mestinon bromide; Kalymin; Regonol; Pyridostigminium bromide.





This pyridinium salt is an analogue of  neostigmine in which the aniline radical is substituted by a heterocyclic ring. For its preparation, pyridine-3-sulphonic acid on fusion with potassium hydroxide and then acidification yields 3-hydroxypyridine. This is treated with dimethylcarbamoyl chloride to yield pyridyl dimethyl carbamate which is quaternized with methyl bromide:



Pyridostigmine bromide, m.p. 152-154°, is a white crystalline powder with an agreeable characteristic odour. It is freely soluble in water. alcohol and chloroform; practically insoluble in ether, acetone and benzene; stored in airtight containers and protected from light.




 Uses : The uses and adverse effects of pyridostigmine bromide are similar as mentioned under neostigmine, but is slower in onset and of longer duration. It is mainly used in the treatment of myasthenia gravis.

Adverse Effect

Adverse effects occur less frequently with pyridostigmine treatment than with neostigmine.


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