QUINIDINE

QUINIDINE

Brand Names : Conquinine, Pitayinee: β-Quinine.

Quinidine, m. p. 174-175°, is a dextro-rotatory stereoisomer of quinine which is present is Cinchona barks to the extent of 0.25-3.0 percent. Most of the compound available in the market is prepared by isomerization of quinine. Quinidine and its salts (e.g. gluconate, sulphate) respond to all the tests for quinine. Both of these alkaloids are distinguished by means of the polarimeter. Quinidine gives blue fluorescence in dilute --- SO. It is very soluble in methanol and chloroform; slightly soluble in alcohol and ether; practically insoluble in petroleum ether.

Uses : Quinidine has cardiac depressant (antiarrhythmic). antimuscarinic and alpha-adrenergic blocking properties. It is used to maintain sinus rhythm after cardioversion of artrial fibrillation and for the prevention of arrhythmias.

Side Effect
Quinidine causes both cardiac and extracardiac adverse effects. They comonly cause gastro-intestinal irritation with nausea, vomiting and diarrhoea.





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