QUNACRINE OR MEPACRINE HYDROCHLORIDE

QUNACRINE OR MEPACRINE HYDROCHLORIDE

Brand Names : Atabrine 2HCl; Atebrine 2 HCl; RP 866; SIN 390; Cinacrine 2HCl; Erion; Acriquine; Acrichine; Palacrin; Metoquine, Italchin.

Quinacrine hydrochloride occurs as a yellow, bitter crystalline powder. It is sparingly soluble in water (1:35); more soluble in hot water; slightly soluble in alcohol and insoluble in n ether, benzene, and acetone; pH of a 1% aqueous solution is about 4.5.
The yellow colour that quinacrine imparts to the urine and the skin is temporary and should not be mistaken for jaundice. It is stored in airtight containers and protected from light.
Uses : Quinacrine was formerly used for the suppression and treatment of malaria but it has been replaced by chloroquine and other antimalarials. It is used in the treatment of giardiasis, for the expulsion of tapeworms and neoplastic effusions in the pleura or peritoneum. Adverse effects include dizziness, headache and mild gastro-intestinal disturbances.







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