ROLITETRACYCLINE

ROLITETRACYCLINE

It is prepared by condensing tetracycline with pyrrolidine and formaldehyde in the presence of t-butyl alcohol. This derivative has been introduced for use by injection. It occurs as a light yellow crystalline powder or fine. pale needles, with a characteristic musty amine-like odour, m.p. l62-165° (dec.). It is more soluble tetracycline and its hydrochloride; soluble in water (Ol in 1.1), alcohol l in 200), acetone, dilute acids and alkalies; very soluble in ether. It is stored in airtight containers and protected from light.

Uses :

Rolitetracycline has antimicrobial activity and uses similar to those of tetracycline hydrochloride.

Side Effect

Shivering and more rarely rigor may be associated with the first few injections of rollitetracy line in infections due to organisms highly sensitive to tetracyclines.



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