SOLAPONE

SOLAPONE



Brand Names : Phenopryldiasulfone sodium; Salapsone. RP 3668; Cimedone; Sulphetrone; Solasulfone: Solasulfonum

Solapsoneis the sodium salt of a tertrasulphonic acid made by condensing dapsone with cinnamaldehyde (a typical Schiff base preparation) in the cold followed by addition of Sodium bisulphite to the resulting conjugated compound, 4,4'-dicinnamylideneaminodiphenyl sulphone.

Solapsone is an almost white powder, becomes anhydrous at in vacuo; exceedingly soluble in cold water, giving a neutral solution; practically insoluble in cold alcohol. Acidcatalyzed hydrolysis readily reverses the bisulphide addition reaction, with formation of cinnamaldehyde, sulphurous acid and a dapsone salt.


Uses :

Solapsone has the action, uses and side-effects of dapsone. It is given as an antileprotic drug to treat leprosy. It is more slowly absorbed than dapsone and is used in much larger doses.


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