STREPTOMYCIN SULPHATE

STREPTOMYCIN SULPHATE




Brand Names : Sesquisulfate; Agri-strep; Streptobrettin, Streptorex, Vetstrep; Sulfato de Estreptomicina; Streptomycini sulfas.


It is a white to light grey or pale buff powder with faint amine-like odour. It is very soluble in water; practically insoluble in alcohol, chloroform and ether; incompatible with acids and alkalies. The sulphate is stable in light and air. Streptomycin and its salts are kept in air-tight containers and protected from light.

Streptomycin sulphate is given by intramuscular injection as a solution in water.

Streptomycin is an aminoglycoside antibiotic mainly used in the treatment of tuberculosis. It is effective in the treatment of plague, tularaemia, and, in conjugation with tetracycline, in brucellosis .

Registance has been observed in strains of most of the organisms reported to be sensitive to streptomycin. Another factor which limits its therapeutic is chronic toxicity. Certain neurotoxic reactions have been observed after the use of streptomycin. They are characterized by vertigo, disturbance of equilibrium and reduced auditory acuity.
In combination with penicillin, streptomycin is used to ièsubacute bacterial endocarditis and postoperative infections. streptomycin is rapidly absorbed after intramuscular injection.

Adverse Effect
Streptomycin can produce nephrototoxicity,respiratory depression, muscular paralysis, hypomagnesaemia, hypocalcaemia, hypokalaemia and some other effects like anaemia, purpura, convulsions, visual disturbances, etc




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