SUCCINYLSULFATHIAZOLE

SUCCINYLSULFATHIAZOLE

Brand names : Sulfenterone; Kaoxidin. Thiacyl; Sulfasuxidine.

It is obtained by refluxing sulfathiazole with a slight excess of succinic anhydride in alcohol or by refluxing p-succinimido benzenesulfonyl chloride with 2-aminothiazole in benzene.

This compound occurs as a white, odourless crystalline powder with unclear m.p. (184-186° and 192-195°). It is stable in air but slowly darkens on exposure to light. It is soluble in water (1 : 4,80O); sparingly soluble in alcohol and acetone and insoluble in chloroform and ether. It emits pungent fumes on heating to melting point. It is soluble in dilute acids and bases and dissolves in sodium bicarbonate solution with evolution of carbon dioxide. It is protected from light

Uses
It is an intestinal antibacterial agent. Due to its slow absorption and low toxicity, it is useful in bacillary dysentery




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