SULFACETAMIDE

SULFACETAMIDE





Brand Names : Acetocid; Bleph10; Acetosulfamine; Sulfacyll; Urosulfone. Albucid: Sulamyd , sulfacet




Sulfacetamide, a simple acetyl derivative of sulphanilamide, was introduced for use in infections of, and injuries to, the eyes; it is used in the form of its sodium salt. It is prepared by diacetylating sulfanilamide with acetic anhydride and then removing the N-acetyl group by selective alkaline hydrolysis ..



It is a white , odourless , crystalline , powder m.p. 182-184* slightly soluble in water (1: 62.5 at 37°) and ether; soluble in alcohol; very soluble in chloroform and hot water; freely soluble in dilute mineral acids and solutions of alkali hydroxides. Its aqueous solutions are acidic to litmus and sensitive to light; they are unstable when acidic or strongly alkaline. It is stored in well-closed containers and protected from light

Uses:




Sulfacetamide is a short-acting sulfonamide which was Miscellane formerly used in the treatment of bacterial infection of the urinary tract. It is absorbed readily from the gartro-intestinal tract, and the concentration in the blood is proportional to the oral dose administered. It is excreted primarily in the urine. Because of its high solubility and ready elimination, it has found considerable use in urinary tract infections, since it is possible to maintain high urinary concentration without danger of kidney damage.

Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more