SULPHOBROMOPHTHALEIN SODIUM...

SULPHOBROMOPHTHALEIN SODIUM...




Brand Names : Bromosulphophthalein: BSP; SBP; Sulphobromophthal Sodium; Sulphobromophthalein; Disodium phenoltetrabromophthaleinsulfonate; Hepartest; Bromthalein; Bromsulphalein sodium; Brom-Tetragnost.

Sulphobromophthalein sodium is a phthalein derivative used as a dye in tests of liver  function. It is prepared by dissolving phthalic anhydride in fuming sulphuric acid, followed by bromination with iodine as a catalyst. The tetrabromophthalic anhydride is then condensed with phenol and  the resulting tetrabromophenolphthalein is sulphonated and converted to the disodium salt.


It occurs as a white, bitter, odourless, crystalline, hygroscopic powder; soluble in water; practically insoluble in alcohol and in acetone. The presence of sulphonic acid groups into the compound decreases the toxicity and increases the water solubility. The compound is injected intravenously and the amount remaining in the blood after a certain time interval is determined colourimetrically. The rate at which the dye is removed from the blood is a measure of the hepatic function.

Uses: Sulphobromophthalein sodium is used as a diagnostic agent for testing the functional capacity of the liver. The test is usually performed in the morning after the patient has taken a fat-free breakfast. No food must be given during the test. The concentration of the dye in the bloodstream is measured at the end of 1 hour and at regular time intervals thereafter to determine the rate of clearance.


Side Effect

Allergic-type reactions have been reported in patients given sulphobromphthalein. Inadvertent subcutaneous infiltration may cause irritation and necrosis.


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