THIAMBUTOSINE

THIAMBUTOSINE





Brand Names : DPT: Su-1906; Ciba-1906.

This thiourea derivative is a phenolic ether and also a tertiary aromatic amine. For its synthesis, the phenolic ether intermediate, 4-butoxyaniline is prepared from 4-aminophenoi.

The other intermediate, 4-dimethylaminophenyl isothiocyanate, is synthesized by catalytic reduction of methyl orange, converting the resulting substituted diamine into an ammonium N-aryl dithiocarbamate by means of carbon disulphide and ammonium hydroxide and then heating with lead nitrate to obtain the required isothiocyanate. Reaction of the two intermediates yields thiambutosine.

It is a white powder, almost insoluble in v/ e treatment


Uses
it is used in t of lepresy in the form of injection and tableTS


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