THIAMINE HYDROCHLORIDE

THIAMINE HYDROCHLORIDE


Brand Names: Vitamin B; Bedome; Begiolan; Benerva; Bequin; Berin; Betabion; Betalin S; Betaxin; Bethiazine; Bevitex; Bewon; Biuno; Bivatin; Bivita; Clotiamina; Metabolin; Thiadoxine; Thiavit; Tiamidon; Tiaminal; Vitaneuron.

Thiamine hydrochloride is a colourless crystalline powder with a faint characteristic thiazole odour; m.p. 248 (decomp). It is soluble in water and glycerol; practically insoluble in chloroform, ether and benzene. On exposure to air, the vitamin absorbs an amount of water forming a hydrate. The article of commerce contains about 4% water which is removable by drying at 100'. In the dry form the vitamin is stable, and heating at 100° for 24 hours does not diminish its potency. In aqueous solution it can . be sterilized at 110°, but if the pH of the solution is above 5.5, it is destroyed rapidly.

One gram of crystalline vitamin B hydrochloride is equivalent to 333,00 I.U. The vitamin is destroyed by alkalies and alkaline drugs such as phenobarbital sodium and by oxidizing and reducing agents. It is preciptated by tannins and by reagents which precipitate alkaloids. It is kept in airtight nonmetallic containers and protected from light. -


Thiamine mononitrate, thiamine nicotinate or vitamin B, mononitrate is similar to thiamine hydrochloride in therapeutic use and dose.



Uses : Thiamine is an essential coenzyme for carbohydrate metabolism. Thiamine deficiency produces beriberi which is characterized by cardiac failure, oedema, polyneuritis, muscular atrophy, cardio- and vascular changes. Thiamine is used in the treatment and prevention of thiamine deficiency.








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