TRICLOFOS-SODIUM

TRICLOFOS-SODIUM

Brand Names : Sch-10159; Sodium Trichlofos; Trichloryl; Tricloryl; Triclos.

This salt of an ester is prepared by esterification of trichloroethanol with orthophosphoric acid by heating at 100° for Ho six hours. The mixture is cooled, diluted, and the triclofos extracted with an organic solvent. Extraction of the organic phase with sodium hydroxide solution furnishes an aqueous solution of triclofos sodium. The compound is crystallized on addition of acetone.
Triclofos sodium is a white, odourless, hygroscopic powder. It is soluble in water (1 in 2); slightly soluble in alcohol; practically insoluble in ether; stored in airtight containers. A2% solution in water has a pH of 3.0 to 4.5. Aqueous solutions slowly decompose, liberating chloride and phosphate ions.

Uses
Triclofos sodium has hypnotic and sedative action similar to chloral hydrate. It is not corrosive to skin and mucous membranes.




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